Duhaime's Law Dictionary


Temozolomide Definition:

A chemotherapy, pharmaceutical product especially effective in treating brain cancer, often in combination with radiation.

Related Terms: Cancer, Oncology

Aso known as"Temodar" and "temodal" (see endnote #2, 2014-02 SunPharma press Release)).

Ed, note: all terms, "telemodar®", "telemodar®" and "Temozolomide®" are registered trademarks).>

In In a 2010 judicial decision of the United States Court of Appeals, Federal Circuit, Cancer Research Technology v. Barr Laboratories, (an intellectual propertypatent) case, the following words were used:
 
 

quot;temozolomide is the active ingredient in the drug Temodar®, approved by the  aMERICAN Food and Drug Administration ("FDA") for the treatment of two types of brain cancer— refractory anaplastic astrocytoma and newly diagnosed glioblastoma multiforme."

"Temozolomide exerts its anti-cancer affect by a process called alkylation. Alkylation damages the DNA of cells, which prevents them from dividing and causes them to die.

 

Temozolomide, Temodal sachets"Temozolomide is given in a capsule form, taken once a day on an empty stomach (1 hour before a meal or 2 hours after). This helps to prevent nausea associated with this medication. You should take this medication around the same time each day. Be sure to swallow the capsules whole, (do not open or chew them) and take with a full glass of water. The dose is dependent on your body size, the regimen your doctor is following, and whether or not it is being used in conjunction with other chemo-therapies or radiation therapy.1

"Temozolomide Capsules, 5 mg, 20 mg, 100 mg, 140 mg, 180 mg and 250 mg are therapeutic equivalents of Merck Sharp & Dohme Corporation’s Temodar® Capsules. These Capsules have annual sales of approximately USD 400-million.2

 

 

 

 

 

 

Temozolomide Capsules are indicated for the treatment of adult patients with newly diagnosed glioblastoma multiforme concomitantly with radiotherapy and then as maintenance treatment and for adult patients with refractory anaplastic astrocytoma who have experienced disease progression on a drug regimen containing nitrosourea and procarbazine."2

 

 

 

French: Témodal et témozolomide.

 

 

 

 

 

 

 

REFERENCES AND CITATIONS

 

 

 

  • ""625 F Cancer Research Technology v. Barr Laboratories, 625 F. 3d 724 - Court of Appeals, Federal Circuit 2010
  • NOTE 2: > [retrieved from the Internet on August 5, 2014 from the then-active link of http://oncolink.org/treatment/article.cfm?c=2&id=315&aid=578] Sun Pharmaceutical Industries Ltd., Sun Pharma announces US FDA approval for generic Temodar,
    17/B, Mahal Industrial Estate, Mahakali Caves Road, Andheri (East), Mumbai 400 093 India, Press Release 2014-092-13 [retrieved from the Internet on 2014-08-14 from http://www.google.ca/url?sa=t&rct=j&q=&esrc=s&source=web&cd=2&ved=0CCcQFjAB&url=http%3A%2F%2Fwww.sunpharma.com%2FMedia%2FPress-Releases%2FPress%2520Release%2520USFDA%2520approval%2520for%2520generic%2520Temodar%2520Capsule.pdf&ei=cIrnU-T7GYb5iQLj-IDYBQ&usg=AFQjCNFsROcB7FsVZo7gHtWQwPudEmyEIA&bvm=bv.72676100,d.cGE&cad=rja]>/li>

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